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However, AMPK’s effects are context-dependent: under nutrient-replete conditions, AMPK-deficient T cells maintain normal responses, but during glucose restriction or metabolic stress, their adaptability is severely impaired (84)

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That prodrug went into LIFT-AD, a randomized placebo-controlled phase 2/3 trial in mild-to-moderate Alzheimer's disease with 287 participants in the primary analysis and 549 dosed overall [19]